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KMID : 0356620140290020202
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Journal of Korean Society of Endocrinology
2014 Volume.29 No. 2 p.202 ~ p.205
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Recurrent Hypoglycemia Triggered by Sorafenib Therapy in a Patient with Hemangiopericytoma
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Lee Si-Won
Lee Eun-Kyung
Yun Tak
Won Young-Woong
Ko Eun-Jeong
Choi Mi-Hong
Choi Sang-Il
Park Sun-Seob
Hong Eun-Kyung
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Abstract
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Targeted therapy has been proven to be one of the most effective cancer treatments. However, some endocrine disorders can occur during treatment with targeted agents. We report the case of a patient who exhibited a wax and wane pattern of hypoglycemia that was attributed to sorafenib therapy. A 32-year-old woman with metastatic hemangiopericytoma visited the emergency department in a stuporous state. Nonhyperinsulinemic hypoglycemia was diagnosed, was exacerbated shortly after sorafenib therapy, and was improved by the cessation of sorafenib with additional glucocorticoid therapy. Patients with metastatic hemangiopericytoma should be carefully monitored with particular attention to hypoglycemia when sorafenib therapy is initiated.
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KEYWORD
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Hemangiopericytoma, Hypoglycemia, Sorafenib
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